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Abstract

FORMULATION AND EVALUATION OF MODIFIED RELEASE TABLET OF DONEPEZIL HYDROCHLORIDE

*Dr. Patel Bhavik N., Patel Devyani B., Dr. Patel Chhagan N.

ABSTRACT

The purpose of present work was a developed sustained release matrix tablet of Donepezil hydrochloride stable and provide sustained therapeutically effective plasma level over a 24 hour period with reduced undesired side effects, and developed dosage form shows better in-vitro drug release than that of marketed available (SR) formulation. Donepezil hydrochloride matrix tablet were prepared by wet-granulation technique using natural polymers Guar gum, Xanthan gum, Karaya gum and pectin a release controlled polymer. The prepared SR tablets were evaluated for thickness, Hardness, friability, drug content and in-vitro drug release.Using experiment design, the prepared formulations evaluated. The optimized formulation E7 containing guar gum and PVP-K30 showed good in-vitro drug release and grater similarity factor with marketed (SR) formulation profile (76.22), and other physicochemical properties that were suitable for SR tablet. Stability study of optimized formulation showed that optimized formulation was stable at accelerated environment conditions.

Keywords: Donepezil hydrochloride, Sustained release, in-vitro drug release, similarity factor (f2), Guar gum


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