WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

FORMULATION AND EVALUATION OF SUSTAINED RELEASE QUETIAPINE FUMARATE TABLET BY USING DIFFERENT POLYMERS

E.Esther Rani*, A.Swapna and Dr. H. Padmalatha

ABSTRACT

The main objective of the present work was to develop sustained release matrix tablets of Quetiapine fumarate by using different polymers viz., Hydroxy methyl propyl cellulose (HPMC) and Carbomer. Varying the ratios of drug and polymer like selected for the study. Quetiapine fumarate is prescribed for the treatment of Schizophrenia. It has a mean half life of 6hrs and administered at least thrice a day. The main objective of the study is to design once a day dosage form which can release the drug for 24hrs. The tablets were prepared by direct compression method. In-vitro dissolution studies showed that F7 has better release profiles when compared to other formulations. Though F4 showed release of 22hrs, the drug release was not constant. The experiment clearly stated that the usage of Carbomer has promoted the sustained release of QPF. Dissolution data was analyzed by Higuchi expression. Stability studies for 6 months indicated that Quetiapine fumarate was stable in the matrix tablets. The DSC and FTIR study revealed that there was no chemical interaction between drug and excipients.

Keywords: Quetiapine fumarate, HPMC, Carbomer, Matrix tablets, Higuchi Model, Direct compression.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More