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Abstract

FORMULATION AND EVALUATION OF FLOATING MINI MATRIX TABLETS OF THIAMINE MONONITRATE

Kiran Kumar*, P.srikanth, M.Ajitha Madhusudan Rao.Y

ABSTRACT

Oral route is the most common route of administration of drugs because of the several advantages this offers. The advantages include the ease of administration, least aseptic constraints and the ease of the manufacture of the dosage form. In the present research Floating mini matrix tablets of Thiamine mono nitrate were successfully prepared with hydrophilic polymers like HPMC K4M, HPMC K15M and HPMC K100M with 5% sodium bicarbonate by wet granulation method with drug: polymer ratios of 1:2,1:3,1:4,1:5,1:6. The buoyancy of mini tablets might be due to release and entrapment of carbon dioxide gas in the polymer matrix. Evaluation parameters of powder blend like bulk density, tapped density, Hausner’s ratio, Compressibility index, Angle of repose were carried out and results showed that the powder has good flow properties The mechanism of drug release was found to be fickian diffusion except for F1 and F3 which followed erosion and all the formulations followed first-order release kinetics. X-ray radiography studies indicated that the optimized formulations floated in the stomach for sufficient time period without any adhesion to the walls of the stomach. Formulated tablets gave satisfactory results for various evaluation parameters like thickness(4mm), hardness(5-6Kg/cm2), weight variation( +/- 10%), friability(less than 0.9%), content uniformity(90%-110%), in vitro buoyancy properties (around 12hrs)and in vitro drug release. F4,F9,F13 formulations were found to be within desired drug release and floating characteristics and among these formulation F9 with lesser floating lag time and drug release more than 90 % was considered to be optimized formulation.

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