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Abstract

EFFECT OF GENTAMICIN TO PREVENT OF INFECTION IN SURGICAL SITE; A RANDOMIZED CLINICAL TRAI (RCT)

Razieh Mohammad Jafari, Mahin Najafian and Soghra Aria Zangeneh*

ABSTRACT

Background: The purpose of this study was to investigate whether gentamicins and normal saline after cesarean delivery and before closing surgical wound reduce the incidence of post-cesarean infection within 1 month follow-up. Methods: We conducted a randomized clinical trial at two university-affiliated hospitals including Imam Khomeini hospital and Razi Hospital, at Ahwaz Jundishapur University of Medical Sciences in 2013. Pregnant women who underwent cesarean delivery were assigned into two groups to receive either 80 mg gentamicinsplus 300 cc normal saline (intervention) (n= 180 cases) or 300 cc normal saline alone (control) (n= 180 cases) (Gentamicine, Sobhan Co, Rasht, Iran; 0.9% Sodium Chloride Injection, Iran Pharmaceutical and Parenteral Co., IPPC, Tehran, Iran). The clinical trial registration code is IRCT2015021221048N1. Inclusion criteria were maximum operation time of 40 minutes and Pfannenstiel incision. Women were excluded if they had weight over 100 kg, immune deficiency, diabetes or high blood pressure. Results: A total of 360 women were included in the final analysis. Surgical wound infection occurred in 7 women in intervention group and 8 women in control group. There was no significant difference in the rate of post-cesarean infection between intervention and control group, respectively 3.9% and 4.4%,p value = 0.5. In addition. Conclusion: Finally we concluded that Gentamicinsplus normal saline in compare with normal saline alone does not reduce the rate of post cesarean wound infection.

Keywords: Cesarean Section, Surgical wound infection, normal saline, Gentamicins.


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