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Abstract

ANTI-OXIDANT AND HEPATOPROTECTIVE ACTIVITY OF PHENOLIC COMPOUNDS OF LEAVES EXTRACTS FROM MENTHA LONGIFOLIA AND MENTHA SPICATA IN DIABETIC MALE RATS

Eman A. Al-Rekabi*

ABSTRACT

Diabetes mellitus is one of the most widely distributed metabolic disorders and occurs in almost all populations of the world at a variable prevalence. The present study was conducted to investigate the effect of phenolic compounds extracted from Mentha longifolia and Mentha spicata on serum malondialdehide (MDA) , ceroloplasmine (CP) , body weight, liver enzymes Alanine Transaminase(ALT) and Aspartate Transaminase (AST) level of diabetic male rats. One dose (200 mg/kg) from each plant were used and the animals were injected intraperitonially for 14 days as one dose/day. The results showed a significant decrease (P<0.01) in the serum (MDA) and (CP) level and a significant increase (P<0.01) in the body weight of the male rats treated with phenolic extractes of M. longifolia and M. spicata at dose 200 mg/kg. and the results showed a significant decrease (P<0.01) in the serum (AST) and (ALT) level of the male rats treated with phenolic extractes of M. longifolia and M. spicata at dose 200 mg/kg.

Keywords: Mentha spicata, Mentha longifolia, MDA, CP, AST,ALT, diabetes mellitus, phenolic compounds.


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