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Abstract

EFFECTS OF REPEATED ADMINISTRATION OF CHROMOLAENA ODORATA ON SELECTED KIDNEY FUNCTIONS PARAMETERS OF WISTAR RATS

Nwachukwu Francis Chukwuedozie*

ABSTRACT

The uneducated indiscriminate increase in herbal usage in complementary and alternative medicines, for the treatment of various diseases may in part contribute to rapid increase in kidney disease around the globe, equally economic and cultural factors associated with these practices are also contributing factor. The present study was conducted to evaluate the effects of crude aqueous extracts of Chromolaena odorata on kidney function parameters. In the study, the rats received repeated dose of 20mg/kg body weight, daily. The kidney function parameters were estimated four days after administration. The results shows that in urea and creatinine, concentration there was definite patterned increase, up to 9 day after administration, and upsurge on 13th day after administration and each result is significantly different from the 13th day after administration (P<0.05a). Creatinine concentration was significantly different from the control (day 0) at P P<0.05, in the entire estimate. Sodium and Chloride ion concentrations decrease from the control and increase on the 13th day after administration. Potassium ion concentration increases from control. Sodium ion concentration was significantly different from the normal at P<0. 05. Potassium and Chloride ion were significantly different (P<0.05), from the control on (9th and 13th) and (5th and 9th) day after administration respectively. Albumin was not significant from normal. From the result, it is glaring that there was some degree of kidney impairment but insufficient to include nephrotic syndrome as the albumin level showed no significant changes.

Keywords: Kidney Health, Chromolaena odorata, Electrolytes, urea, Creatinine, Albumin.


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