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Abstract

EFFECT OF THIRST STRESS ON THE PRODUCTION OF PHYTOCHEMICAL CONSTITUENTS OF RHAZYA STRICTA PLANT AND ANALGESIC ACTIVITY OF ITS BIOACTIVE FRACTIONS

Usama Shaheen*, and Muhammad Ahmed

ABSTRACT

Rhazya stricta Decne is an important folkloric medicinal plant used in
Saudi Arabia and other countries of Arabian Peninsula to relieve
various diseases. Alkaloids and flavonoids represent the most active
secondary metabolites of this plant. Rain is the only source of water for
desert wild plants. This search includes the estimation of total phenol,
flavonoids, and alkaloids in two plant samples. Describing the effect of
prolonged thirst on the production of these constituents in the plant and
assessment of the analgesic activity of its different extracts. The total
phenol and flavonoid contents were estimated using spectrophotometer
assay by Folin-Ciocalteau and AlCl3 reagents respectively. While the
concentration of its alkaloids was determined spectrophotometrically
through the formation of ion-pair complex with acidic dye (methyl orange), followed by
measuring the absorbance of produced color at λmax 530 nm. Also, the analgesic activity of
ethanol extract, alkaloid fraction, and phenol rich fraction were determined by hot plate test.
The result of these assays found that the alkaloid content was decreased in the absence of rain
while the phenol and flavonoid contents were increased by thirst in a long period of no rain.
The ethanol extract (20 mg/kg) and Phenol fractions (10 and 20 mg/kg) were found to exhibit
significant analgesic activity in comparison with the stranded.

Keywords: Rhazya stricta, Secondary metabolites, Thirst, Alkaloids, Flavonoids, Analgesic activity.


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