WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

THE LEVELS OF CORTISOL, INSULIN, GLUCOSE AND HBA1C IN OVERT HYPOTHYROID IRAQI PATIENTS

Ali Shalash Sultan* and Dhelal Abdul Khaliq Jumma

 

ABSTRACT

The present study aimed to investigate the cortisol and insulin levels
and their relationship with increasing level of TSH in the overt
hypothyroid male patients. The study was carried on 48 subjects in the
Specialist Center of Endocrine and Diabetic Diseases in Baghdad
province at Rusafa region, near AL-Kindey Hospital.The study began
on10/10/2014to14/2/2015.The subjects were divided into 2 groups
(control and hypothyroid).Each group included 24 males,their ages
ranged between20-60years.The results showed a significant(P˂ 0.01)
increase in the level of TSH in overt hypothyroid patients (41.74±
3.61mu/l) in comparison with control (1.97 ± 0.264mu/l).Levels of
T4nmol/L (48.59 ± 0.98) showed a significant (p˂0.01) decrease in comparison with control
(80.12±3.09). T3nmol/L (1.31±0.14); (1.52±0.083) levels showed not significantly (p≥0.05)
between two groups respectively.Cortisol levels (274.08 ± 9.37) ng/ml increased
significantly(P<0.01) in the patients group in comparison with control
group(174.33±13.55).Insulin (15.13±1.14) μIU/ml increased significantly(P<0.01) in the
patients group in comparison with control (8.28 ± 0.76.Glucose levels mmol/l in patients
(4.84±0.15) and control group(4.98±0.11)were not significant(p≥0.05).HbA1c(%) levels in
the study group (5.50±0.18;5.50±0.18) were not significant (p≥0.05)respectively.We
cocluded from this study that that increasing levels of TSH causing an elevation of cortisol
levels among overt hypothyroid patients with increasing insulin levels that too much cortisol
in the system can induce a conversion of T4 to an improper form of T3 called reverse T3
(rT3)and any increased endogenous secretion of cortisol, altered thyroid hormone metabolism
that overt hypothyroidism causes elevated cortisol levels, presumably due to both decreased
clearance and blunted negative feedback of cortisol on the hypothalamic pituitary-adrenal
axis(HPA).

Keywords: Thyroid gland, overt hypothyroidism, cortisol, insulin.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More