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Abstract

NANOCARRIER FOR TRANSDERMAL DRUG DELIVERY SYSTEM

Nilam Gadge*

ABSTRACT

These nanocarriers (nanoparticles, nanoemulsion, dendrimers, liposomes, etc) can be made of a lot of different materials, and they are very different in structure and chemical nature. It offers multiple sites to avoid local irritation and toxicity, yet it can also offer the option of concentrating drugs at local areas to avoid undesirable systemic effects. This difficulty is because the stratum corneum of skin acts as an efficient barrier that limits penetration of drugs through the skin, and few noninvasive methods are known to significantly enhance the penetration of this barrier. In order to increase the range of drugs available for transdermal delivery, the use of nanocarriers has emerged as an interesting and valuable alternative for delivering lipophilic and hydrophilic drugs throughout the stratum corneum with the possibility of having a local or systemic effect for the treatment of many different diseases.

Keywords: nanoparticles, nanoemulsion, dendrimers, liposomes, etc.


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