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Abstract

REVIEW ON VARIOUS APPROACHES ON PREPARATION, CHARACTERISATION AND APPLICATIONS OF POLYMERIC NANOPARTICLES

B.Senthilnathan*, H.Ameerkhan, Aswini Sofia PI, M.Abirami, T.Bharath, T.Ajithkumar and A.Maheswaran

ABSTRACT

Nanoparticles have evolved as a promising tool for the efficient delivery of drugs to alter and improve the pharmacokinetic and pharmacodynamic properties of various types of drug molecules. The particle size of nanoparticle in the range of 10-1000nm. There has been a considerable research activities in the area of drug delivery using this nano particulate drug delivery system as carrier for many drugs, because of their targeted drug delivery system, controlled and sustained release properties, sub-cellular size, bio-adaptability, biocompatibility with tissues and cells. The proper selection of polymers helps to design the drug release for specific location, increases the therapeutic effect and minimizes the side effects. In this review the various aspects of nanoparticle preparation, characterization, limitation, nanoparticle types, types of polymers, advantagesdisadvantages and their applications were discussed.

Keywords: Particle size, Zeta potential, Bioavailability, Targeted drug delivery.


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