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Abstract

NOVEL BIOACTIVE FLAVONOID FROM FLOWERS OF CALOTROPIS GIGANTEA LINN.

Dr.Anurekha Yadav*

ABSTRACT

Calotropis gigantea Linn. is commonly known as Ak in Hindi. It is a
shrub or small tree, eight to ten feet in height, bearing unscented white
flowers with five pointed petals and a small elegant crown rising from
the centre which holds the stamens. The plant has oval, light green
leaves and milky stem. The milky exudation from the plant is corrosive
in nature, having mercury like effect on human body and is therefore
sometime referred to as vegetable mercury. The plant mainly contains
cardiac glycosides. Earlier workers have isolated various constituents
from this plant, the present paper deals with isolation and structural
elucidation of a new compound A, identified as 3,5,4'-trihydroxy-
6,7dimethoxyflavone-3-O--L--arabinopyranosyl-5-O--Dgalactopyranosyl-(
1→4)-O--D xylopyranoside, along with a known
compound B, identified as Myricetin from the methanol soluble ethanolic extract of the flowers
of the plant. The isolated compounds were identified and characterized by various colour
reactions, chemical degradation and spectral analysis. Flower extract of the plant was utilized
For Behaviour Despair Study in animal model, by employing Forced Swim Test and Tail
Suspension Test. These tests indicated the potential antidepressant effect of the plant extract.

Keywords: Calotropis gigantea Linn., Ascelpiadaceae, Flowers, Myricetin, Flavonoidal Glycosides.


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