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Dr. Radhika Parasuram Rajam and Chetan Borkhataria*


Purpose: The aim of the present investigation was to formulate and evaluate the gastro-retentive floating drug delivery system of glipizide (as microsphere), that would retain the drug in stomach and continuously release the drug in controlled manner up to a predetermined time leading to improved bioavailability. Methods: In the present investigation eight formulations of glipizide were prepared as the floating microspheres using hydroxypropylmethylcellulose (HPMC) and eudragit RS100 polymers. Results: The densities of floating microspheres (0.475-0.975 gm/cm3) were found to be less than the density of gastric fluid (1.004 gm/cm3), therefore showed an extended floating time of more than 12 h over the gastric fluid. The percentage entrapment efficiency of prepared floating microspheres was 76.19 - 41.32%. The scanning electron microscopy confirmed the hollow nature of microspheres with pores on the surface of floating microspheres, which imparted floating properties to the prepared floating microspheres. F4 formulation shows the greater entrapment efficiency in the range of (64.76 %) with the ratio of drug: polymer (HPMC: Eudragit RS 100) (1:4:3). F4 formulation shows good in-vitro release with (99.12 %) in 12 h in 0.1 N HCl. The kinetic study of prepared floating microspheres showed controlled drug release by matrix diffusion Process with zero order release rate kinetics. Conclusion: The formulated gastro retentive floating drug delivery systems of glipizide showed good physicochemical properties, good stability and controlled drug release pattern, thereby improving the bioavailability of the drug and also manage the complicacy of the diabetes in a better manner.

Keywords: Floating microspheres, Glipizide, HPMC (hydroxypropylmethylcellulose).

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