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Abstract

SPECTROPHOTOMETRIC ESTIMATION OF ZALTOPROFEN FROM BULK DRUG AND TABLET DOSAGE FORM

Rajan V. Kalamkar*, Shailesh J. Wadher, Sunita S. Gagare and Ashish S. Jain

ABSTRACT

Two Simple, accurate, precise and sensitive spectrophotometric methods for estimation of Zaltoprofen (ZAL) have been developed and validated. The zero order spectroscopic method (Method I) and area under curve method (Method II) have developed. The proposed methods are validated according to ICH Q2B guidelines. The Zaltoprofen gives maximum absorbance at 227nm in Methanol: Water (1:4) and observed linearity 2-18 μg/ml for zero order method and area under curve method. The stability of drug in Methanol: Water (1:4) has been studied and drug shows good stability. The recovery by method I and method II are 99.87 ± 0.532, 99.62±0.712 respectively. The both spectrophotometric methods can be applied for routine analysis of Zaltoprofen in tablet formulation and in bulk drug.

Keywords: Zero order method, area under curve method, UV spectrophotometer, absorbance.


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