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Abstract

ANTIOXIDANT AND CYTOTOXIC POTENTIAL OF THE PLANT HOLIGARNA ARNOTTIANA HOOK.F. BARK ETHANOLIC EXTRACT

Ayana Ravi* and Oomen P. Saj

ABSTRACT

The present study was aimed to reveal the antioxidant potential and cytotoxic activity of the ethanolic bark extract of Holigarna arnottiana plant. The in vitro antioxidant potential was determined by DPPH scavenging activity, Hydroxy radical scavenging activity, singlet oxygen scavenging activity and superoxide radical scavenging activity. The cytotoxic activity was detected by MTT assay and DLA assay. The results showed that the extract has a high DPPH radical scavenging activity with an IC 50 value of the extract was 15.6±0.1μg/mL and that of the standard ascorbic acid was 24.92±0.03μg/mL. In superoxide radical scavenging method the IC50 value was 49.2±0.2μg/mL and that of the standard was 95.1±0.3. The IC50 value in singlet oxygen analysis was 39.1±0.1μg/mL and that of standard was 38.6μg/mL. For Hydroxy radical analysis the IC50 value was 73.6±0.1μg/mL. In tryphan blue exclusion assay of cytotoxicity, the extract showed a CT50 value of 2.8μg/mL. In MTT assay the MCF cells showed a CT50 value of 50μg/mL and MCF 15 cells the CT50 value is 30μg/mL.

Keywords: Antioxidant, cytotoxic, Holigarna, DPPH, MTT.


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