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Abstract

PHARMACO-EPIDEMIOLOGY OF DRUGS USED IN POST CATARACT SURGERY PATIENTS IN TERTIARY CARE HOSPITAL IN NORTH INDIA - A PROSPECTIVE OBSERVATIONAL STUDY

Neeraj Kumar Agrawal*, Neeti Gupta, D C Dhasmana, Renu Dhasmana, Amit Maitreya and Anuradha Raj

ABSTRACT

Drug utilization studies aim to provide feedback to the prescriber and to create awareness among them about rational use of medicine hence we planned this study through evaluating the prescriptions in post cataract surgery patients in tertiary care hospital in north india. This prospective study was carried in the department of ophthalmology & Pharmacology over a period of 6 months. The data collected for post cataract surgery patients included the patient’s demographic details and the drugs prescribed. Data were analyzed for drug use pattern and cost of drugs. In a total 674 prescriptions (1700 drugs) were analyzed; all drugs (100.0%) were prescribed by topical route as eye drops. Moxifloxacin (77.40%) and Prednisolone (77.40%) were found to be the most frequently prescribed drugs. Out of 674 prescriptions, 352 (52.22%) contained three drugs, the most common triple combination being Moxifloxacin, Prednisolone and Ketorolac (21.36%). Dexamethasone plus Ofloxacin (19.88%) being the only prescribed Fixed dose combination (FDC). FDC Dexamethasone plus Ofloxacin treatment strategy was found to be the cheapest among all combination therapy. Moxifloxacin, prednisolone and Bromofenac combination was remain on highest cost. Our study shows that Fluoroquinolines and corticosteroids were the most frequently prescribed drug groups in post cataract surgery patients. Irrational prescribing among clinicians existed mainly in form of higher cost of treatment. It should be clear among prescribers that rational therapy can play an important role for convenience of patients as well as society in terms of disease burden, adverse events and treatment cost.

Keywords: Cost analysis, Drug use pattern, Post cataract surgery, North-India.


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