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Abstract

SPECTROPHOTOMETRIC SIMULTANEOUS DETERMINATION OF ASPIRIN AND ESOMEPRAZOLE MAGNESIUM IN SYNTHETIC MIXTURE BY RATIO DERIVATIVE METHOD.

Dr. Bhavna A. Patel*, Jinesh A. Doshi, Shraddha J. Parmar and Dr. A. D. Captain

ABSTRACT

A sensitive, precise, accurate and simple UV spectrophotometric methods have been developed for the Simultaneous determination of Aspirin and Esomeprazole magnesium in API and Dosage form. The method depends on first derivative of the ratio-spectra by measurements of the amplitudes at 221 nm for Aspirin and 291 nm for Esomeprazole magnesium. In ratio derivative spectroscopy, analytical signals were measured at wavelengths corresponding to either maximums or minimums for both drugs in first derivative spectra of ratio spectra obtained by using either spectrum as divisor. Methanol was taken as a solvent. Calibration graphs were established for 20 -50 μg/ml for Aspirin and 5-30 μg/ml for Esomeprazole magnesium. The %R.S.D. values for intraday precision study and inter-day study were <1.0%, confirming that the method was sufficiently precise. The method can be successfully applied for the simultaneous analysis of both drugs in pharmaceutical dosage forms and statistical analysis of the data revealed that both the methods are precise, accurate, reproducible and suitable for the routine quality control analysis.

Keywords: Aspirin, Esomeprazole magnesium, Spectrophotometric, Ratio derivative spectroscopy method.


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