WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

SYNTHESIS, MOLECULAR PROPERTIES PREDICTION AND BIOLOGICAL ACTIVITY OF BENZIMIDAZOLE TRITHIOCARBAMATE DERIVATIVES

A.N.V.Sunitha, S. Sharada, M.S.N.Sandhya, T.Saritha Jyostna*

ABSTRACT

In the present investigation, a series of novel Benzimidazole trithiocarbamates have been synthesized. It deals with the design and calculation of Molecular Properties, Druglikeness, Lipophilicity and solubility parameters using Molinspiration, Molsoft softwares. Toxicity parameters were calculated using Osiris software. All the compounds are non-toxic, fulfill the solubility requirements and passing oral bioavailibility criteria. The compounds were synthesized and characterized by IR, 1H NMR and Mass Spectral analysis followed by antimicrobial screening. Most of the synthesized compounds (4a-4f) were found to be on conformity with Lipinski’s “Rule of Five” and other parameters, for their onward screening for antimicrobial activity as oral active drugs.

Keywords: Benzimidazole, Trithiocarbamate, Molinspiration, Molsoft, Osiris, Antimicrobial activities.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More