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Abstract

SYNTHESIS, CHARACTERIZATION AND EVALUATION OF BIOLOGICAL ACTIVITY OF SOME NOVEL BENZIMIDAZOLE DERIVATIVES

*Maruthamuthu, Bharathi Dileepan, Shameela Rajam, B.R. Venkatraman, Christina Ruby Stella, Ranjith

ABSTRACT

The reaction of benzoic acid derivatives with ammonium thiocyanate yield 4-thiocyanatobenzoicacid. The thiocyano-benzoicacid was condensed with o-phenylenediamine and carbon disulphide to get benzimidazole. These compounds were synthesized in good yield and their structures were confirmed by IR, 1H-NMR and 13C-NMR. Antimicrobial activity against bacteria and fungi, anti-inflammatory activity and analgesic activity were studied for the synthesized compounds.

Keywords: Benzimidazole, thiocyanate, o-phenylenediamine, pharmacological activity.


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