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Abstract

FORMULATION, DEVELOPMENT AND EVALUATION OF FAST DISINTEREATING COMBINATION AMLODIPIN BESYLATE AND ATENOLOL TABLET USING NATURAL DISINTIGRANT

Yadav Nilesh M*, Kumar Rachana S, Dr. Kshirsagar Sanjay J.

ABSTRACT

The present study aimed to develop fast disintegrating tablets of
Amlodipine besylate and Atenolol using natural disintegrants like Guar
gum, Gum Karaya & synthetic super disintegrants like
Croscaramellose sodium, Sodium starch glycolate and crospovidone.
Disintigrant concentration was taken in this studies 1%, 2%, 3%.
Precompressional studies revealed good micromeritic properties of
powder blend. Various Formulations of were prepared by direct
compression method and were evaluated for their physico chemical
properties, drug release and stability studies The hardness, friability,
drug content and disintegration time of fast dissolving tablets were
found uniform and reproducible. Dissolution test shows that 3 % w/w
concentration was found optimum for both disintigrant. Optimized
formulation was compare with marketed formulation. Drug release of
marketed formulation was only 97.65% AML 98.91% ATEN at the end of 24 min which is
much less as compared to the optimized batch (F3 & F6) which showed drug release of
101.75% AML 100.52% ATE for F3 batch and 99.92% AML 100.51% ATEN for F6 batch at
the end of 18 min.

Keywords: Guar gum, Gum karaya, natural disintegrant, Fast disintegrant tablet.


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