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Abstract

FORMULATION OF MULTICOMPONENT COLD AND COUGH SYRUP

Saddamhusen Jahangir Mulla*, Kapileswar Swain, Sambhaji Deshmukh, Afaque Raza M. Ansari, Dheeraj Ahale and Ishan Prasanjit

ABSTRACT

The Multicomponent syrup formulation of the present experiment contains one or more other drugs for obtaining more than one therapeutic result from a single dose. An antitussive drug such as codeine, pholcodeine. Noscapine, Dextromethorphan, Chlophedianol are used for relief in coughing. These are mostly opoids and non opoids. Non-narcotic antitussives include which is a synthetic derivative of morphine with no analgesic or sedative properties and which is usually included as a constituent of many compound cough preparations sold over the counter. It is a synthetic derivative of morphine with no analgesic or sedative properties. It is as effective as codeine in suppressing acute and chronic cough when given orally. Further, nasal decongestant is incorporated for relief of the upper airway congestion often accompanying disorders such as rhinitis and upper respiratory infections. Many H1 antihistamines have been conventionally incorporated to antitussive/ expectorant formulat ions. They effort relief in cough due to their sedative and anticholinergic actions, but lack selectivity for cough centre. They have no expectorant action, may even reduce secretions by anticholinergic actions. Example, Chlorpheniramine, Diphenhydramine, promethazine etc. Therefore, formulation containing antitussive, nasal decongestant and antihistamine can avoid need of drug taking separately. This will lead to reduce frequency of administration and increased patient compliance.

Keywords: Multicomponent syrup, Chlorpheniramine, Diphenhydramine, anticholinergic actions.


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