WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

STABILITY INDICATING ASSAY OF LOPERAMIDE BY RPHPLC

Amrita Jain *, B.K. Dubey , Kamaal Ahmad, Amit jain

TIT College of Pharmacy, Bhopal, India.

ABSTRACT

Loperamide is very sensitive drug. It is very unstable drug due to presence of hydroxy group. It is used as antidiarrheal drug. Loperamide binds to the opiate receptor in the gut wall. Loperamide increases the tone of the anal sphincter. It is not significantly absorbed from the gut and has no effect on the adrenergic system or central nervous system. Loperamide is slightly soluble in water and freely soluble in organic solvents. To increase its stability generally used it as hydrochloride form. Rphplc is a very sensitive method to determine the stability of any drug. It is based on adsorption. When mixtures of components are introduced into a HPLC column they separate according to their relative affinities towards the stationery phase.

Keywords:


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More