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Abstract

PHYTOCHEMICAL AND ANTITUBERCULAR SCREENING OF THE LEAF EXTRACTS OF FOENICULUM VULGARE

*Shanmugakumar S.D1, Satheesh Kumar Gunasekaran1, Hyma p2, Anil G3, Praveen A3 and Rajanikanth D3

1, 3 Department of Pharmaceutical Chemistry, Jyothishmathi College of Pharmacy, Turkapally (V), Shamirpet (M), R.R. District-78.
2 Department of Pharmaceutics, Jyothishmathi College of Pharmacy, Turkapally (V), Shamirpet (M), R.R. District-78.

ABSTRACT

Foeniculum vulgare is a perennial herb native to southern Europe and Mediterranean Sea. It has a wide range of biological potential which comprises of both pharmacological and antimicrobial perspectives. In the present investigation, the leaf extracts (pet ether, chloroform and methanol) of Foeniculum vulgare were been exposed to combat against Mycobacterium tuberculosis using BACT/ALERT TB assay method. Phytochemical Screening revealed the presence of secondary metabolites such as phenols, glycosides, terpenoids, alkaloids, saponins, flavanoids and tannins. Pharmacognostical investigation revealed the amount of inorganic salts present in the plant in the form of total ash content (10.53), acid insoluble ash (0.14) and total ash content (0.18) respectively. The corresponding total flavanoids content found in the chloroform extract, pet ether extract and methanol extract were found to be 0.186,0.049 & 0.086 respectively. In vitro antimycobacterial screening revealed that both pet ether and methanolic extracts Showed resistant against Mycobacterium tuberculosis. On contrary, chloroform extract of Foeniculum vulgare showed antimycobacterial activity at the concentration of 60 mg/mL by BACT/ALERT TB assay method.

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