WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

EFFECT OF ROYAL JELLY ON DNA INTEGRITY OF EPIDIDYMAL SPERMS IN VASECTOMIZED AND NON- VASECTOMIZED MICE

Saad S. Al-Dujaily*, Majeed H. Nawar, Mena W.Hatem, Rushdi S. Al.Hadithi, Sabah N. Alwachi

ABSTRACT

Background: Fresh royal Jelly contains vitamins, proteins, enzymes, amino acids and other minerals. But the role of royal jelly on sperm DNA normality was unknown. Objective: The main aim of the study was to assess the effects of royal jelly on certain sperm DNA integrity of obstructive azoospermia for using in assisted reproduction technologies( ART). Materials and Methods: In this study, 240 mature fertile male mice (8-12) weeks old were used, and divided in two main three groups according to the period of Royal Jelly (RJ) orally administration .Each group divided into four sub groups one ,two ,three month :namely :Group one without orally administration of RJ and without vasectomy(R-V-).Group two orally administration of RJ without vasectomy(R+V-),Group three not orally administration of RJ with vasectomy (R-V+), Group four orally administration of RJ with vasectomy (R+V+).In Each period the male mice were sacrificed and certain sperm function parameters were recorded . Results: This study showed a highly significant (P <0.05) improvement in certain sperm function parameters i.e the sperm concentration, active sperm motility grade A and B, morphologically abnormal sperms (MAS)and DNA abnormal using acridine orange test, Especially in the case of those with normal sperm parameters with a significant decrease in the proportion of abnormal sperm morphology with a decrease clearly and significantly (P <0.05) the results of epididymal sperm showed a highly significant (P<0.05) decrease in DNA abnormality by using Royal jelly Following one, two, three month of RJ orally administration of Vasectomized male mice. The best result that improve sperm characteristic was following RJ administration for two months. Conclusions: It was concluded from the present study that the RJ orally administration enhance strongly certain sperm function parameters of vasectomized male mice. This result indicates the possibility to use this nutrient for male factor infertility causes especially those with obstructive azoospermia to increase the chance of pregnancy through one of assisted reproductive technologies programs.

Keywords: Royal jelly, obstructive azoopermia, vasectomy, acridine orange, DNA abnormal sperms.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More