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Abstract

FORMULATION AND EVALUATION OF GATIFLOXACIN TOPICAL SEMISOLID DOSAGE FORMS

Mohamed A. El-Nabarawi*, Ahmed H. El-Shafai and Dina M. Mahmoud Abdelfattah

ABSTRACT

The aim of this work is to formulate Gatifloxacin in different semisolid
preparations including gels and emulgels of good rheological and
release properties. All formulations contained 0.1w/w%
Gatifloxacin(GF) concentration. Results showed that all semisolid
formulations depicted acceptable physical properties, all gel and
emulgel formulations followed non Newtonian, pseudoplastic flow,All
formulations depicted thixotropic behavior with varying recovery
rate.Polymers and formulations of lower viscosities achieved rapid
recovery.Sodium carboxy methylcellulose(SCMC) gel(2w/w%)showed
the most rapid recovery compared to other gel and emulgel
formulations, Polymer concentration highly affected the degree of
shear rate and shear stress. It was found that FEg7 depicted the highest
drug release and permeation compared to the other emulgel formulations .Therefore it is the
most suitable formulation for topical formulation.

Keywords: Gatifloxacin, Gel, Emulgel, Polymers.


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