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Abstract

HYPOGLYCEMIC STUDY OF ETHANOLIC EXTRACT OF MIKANIA CORDATA LEAF

Fatema Nasrin, Md. Lukman Hakim*, Mohammad Rezaul Hassan, Nadira Afroz, Md. Hasif Ikbal, Shofiul Azam

ABSTRACT

Besides synthetic drugs, plants derived drugs are also used to manage diabetes. In this study ethanolic leaf extracts (200 & 400 mg/kg body weight) of Mikania cordata were evaluated for hypoglycemic potency. Oral glucose tolerance test was performed on mice at 0, 30, 60, 90 and 120 minutes after glucose (2 mg/kg) administration to determine the rapidity of the extracts to reduce blood glucose level. The extracts exhibited rapid glucose reduction rates and achieved statistical significance (p<0.05 & P<0.01) compared to normal control. An intraperitoneal injection of alloxan (150 mg/kg body weight) was given per mouse to induce diabetes and the animals with blood glucose levels more than 11 mmol/L selected for the experiment. During a study of 14 days both extracts reduced blood glucose level (38.04% for 200 mg/kg & 47.72% for 400 mg/kg body weight) effectively as well as achieved statistical significance (p<0.01) compared to diabetic control, metformin hydrochloride (100 mg/kg body weight) served as positive control. One way analysis of variance (ANOVA) followed by Dunnett’s multiple comparison test was performed to analyze the statistical significance of the values. The extract was found safe up to 2000 mg/kg body weight consumption by following acute toxic class method and reduction of body weight in diabetic mice (3.25% & 5.24% respectively for 200 & 400 mg/kg body weight) was observed. Thus the study revealed and corroborated the hypoglycemic significance of the leaf of Mikania cordata.

Keywords: Mikania cordata, Alloxan, Diabetes mellitus, Metformin hydrochloride, Oral glucose tolerance test.


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