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Dr. T. S. Muralidhar*, H.V. Anil Kumar , Aamir Javed, Juganta Das, C. Chandrasekhar Reddy


Alcohol can affect the hypothalamo-pituitary gonadal axis leading to impotence and sterility by various mechanisms of action. Until recently, alcohol induced liver disease was considered to be primarily responsible for sexual dysfunction in alcoholic men. Ethanol impairs testosterone production by being a direct testicular toxin and by interfering with pituitary luteinizing hormone secretion. In chronic alcohol fed rats, testicular atrophy is associated with reduced plasma testosterone levels by reducing the number of LH binding testicular receptors and also by interfering with the enzymes involved in testosterone biosynthesis. Healthy Male Wister rats were selected for this study, exposure of alcohol with 6% alcohol in feeding bottles orally for 90 days, compared to normal – control rats, the parameters were studied are Mounting Index (MI), Total Sexual Behaviour (TSB), Sperm count, Serum Testosterone by RIA methods, histopathology of target organs and Pituitary were observed under special Histochemical staining: AB-BR-OFG method. In this present study Total sexual behavior (TSB) in normal rats showed: 210.0 ± 0.56 compared to alcohol exposed rats: 260.0 ± 0.96, Sperm count in normal rats: 61.33 ± 0.47 and alcohol exposed rats: 55.33 ± 0.30, Serum testosterone levels in normal rats: 4.62 ± 0.05 and in alcohol exposed rats: 2.44 ± 0.02, histopathological evaluations showed drastic toxic effects in alcohol exposed rats and the control group were showed compact cellular architecture. Conclusion: The increased blood acetaldehyde levels leads to impaired testicular functions and behavioral stress leading to sexual dysfunctions with reduced hormonal profiles.

Keywords: Alcohol, Serum testosterone, Sexual dysfunctions, Total Sexual Behavior (TSB), Sperm count, histopathological profiles.

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