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Abstract

TOXICITIES ASSOCIATED WITH ENGINEERED NANOPARTICLES

Jadhav A.S.*, Phalke P.L, Gadhave M.V., Thorat R.M. and Gaikwad D.D.

ABSTRACT

This Review shows that humans have always been exposed to tiny particles via dust storms, volcanic ash, and other natural processes to cause hazardous effects on body. By the development of nanoscience and nanotechnology, knowledge of interactions between engineered nanomaterials and cells, tissues and organisms has become very important, especially in relation to possible hazards to human health. This review give an overview of current research on nanobiointeractions, with a focus on the effects of ENP and their interactions with live cells. We summarize the Types of ENPs And Also in vivo and in vitro studies of ENPs. Cytotoxic effects are also discussed. Animal and human studies show that inhaled nanoparticles are less efficiently removed than larger particles by the macrophage clearance mechanisms in the lung, causing lung damage, and that nanoparticles can translocate through the circulatory, lymphatic, and nervous systems to many tissues and organs, including the brain, causing abnormal function or cell death

Keywords: Engineered Nanoparticle, Endocytosis, Red blood cell, Silanols, Poration, Cytotoxicity.


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