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Abstract

SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME NOVEL PYRAZOLINE AND FLAVONE DERIVATIVES DERIVED FROM FURAN CHALCONES

R. A. Shastri*

ABSTRACT

A new series of 1-(3-(2-hydroxyphenyl substituted )-5-(furan-2-yl 4,5dihydropyrazol-1-yl) ethanone(4a-g) and 2-(furan-2-yl)-4Hchromen- 4 -one derivatives(5a-g) were synthesized by reacting 3- (Furan-2yl)-1-(2- hydroxyl phenyl substituted ) prop-2-en-1one (3ag) with hydrazine hydrate in acetic acid and DMSO in catalytic quantity of iodine respectively. These compounds were characterized by means of their IR, 1H NMR spectroscopic data. The synthesized products were evaluated for their antimicrobial activity .All the compounds exhibited significant antibacterial and antifungal activity.

Keywords: Chalcones, pyrazolines, flavones, furan, antibacterial, antifungal activity.


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