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Shinkar Dattatraya Manohar*, Ghule Arpan Ramakrishna, Saudagar Ravindra Bhanudas


Liquisolid technique is a new approach for delivery of drugs through oral cavity. This technique is suitable for poorly or water insoluble drugs and also for immediate or sustained release formulations. The technique is based upon the admixture of drug loaded solutions or liquid drug with appropriate carrier and coating materials to convert into acceptably flowing and compressible powder. Addition of additives improves the technique. The selection of non-toxic hydrophilic solvent, carrier, coating excipients and its ratios are independent of the individual chemical entities. Indirectly its leads to enhancement of Bioavaibility. Liquisolid tablet of drug EPM were prepared by using PEG-400, as non volatile liquid vehicle and Avicel PH 102, Aerosil 200 as carrier and coating materials, CCS as superdisintigrant respectively.EPM is BCS class 2 drugs which is having poor water solubility and Bioavaibility (13%), so it is suitable for Liquisolid technique. Also EPM is having daily dose 400-800mg which is high to give at once so to reduce the dose we prepared the sustained release tablet which reduce the dose and also give the sustained drug release.FTIR and DSC studies reveals that there was no possible interaction between drug and tablet excipients. All the formulation was evaluated for disintegration time, hardness and friability time, in-vitro dissolution study.

Keywords: Eprosartan mesylate (EPM), Liquisolid, PEG 400, Aerosil 200, Avicel 102.

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