WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

DEVELOPMENT OF SAFRANAL NIOSOMAL IN-SITU NASAL GEL FORMULATION

*Dr.Chaudhari Shilpa P., Bhandurge Nitin., Kolhe Sadhana S., Ratnaparkhi Mukesh P.

Marathwada Mitra Mandalís College of Pharmacy, Thergaon, Pune-33,University of Pune, Maharastra, India.

ABSTRACT

The purpose of the present investigation was to prepare and evaluate formulations of safranal to improve solubility, stability and facilitate the blood brain barrier crossing of the drug. Niosomes are prepared using various surfactants in different ratios with cholesterol, and optimized based on vesicle size, drug entrapment, drug release and effect of sonication. Then to increase resident time of formulation in the nasal cavity optimized niosomal formulation (B1) further formulated in to in-situ nasal gel using surface response factorial Method. Concentration of Pluronic F-127 and gelrite were used independent variables as the polymers exhibited the phase transition behaviour and gelation temperature and gelation pH was used as dependent variable. The optimised gel concentration (pluronic F127: gelrite,(17.3:0.07) was then used to formulate the in situ niosomal nasal gel The prepared formulation was then characterized for drug loading, content uniformity, in‐vitro drug diffusion, mucoadhesive strength, gel strength, viscosity and gelation temperature. The formulation so prepared was in the liquid state at room temperature while turned into a gel at the pH and temperature of the nasal cavity. Formulation showed the increased bioavailability of drug in in-vivo experiments.

Keywords:


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More