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Shinkar Dattatraya Manohar*, Aher Nitin Sanjay and Saudagar Ravindra Bhanudas


This project is focuses on mainly floating-bioadhesive system. One of the disadvantages of floating systems is that they require a sufficiently high level of fluids in the stomach for the drug delivery buoy to float therein and to work efficiently. However, this limitation can be overcome by coating the dosage form with bioadhesive polymers, thereby enabling them to adhere to the mucous lining of the stomach wall. Therefore these disadvantage can be overcome by formulating floating-mucoadhesive tablet. Cefuroxime axetil is a second generation cephalosporin, BCS Class II drug, its solubility in aqueous solvents is negligible, acid stable and completely absorbed in gastric pH. The biological half-life is 1-1.6 hours and bioavailability in the stomach is 37% and its dose has high frequency of dose i.e. twice a day. To enhance the bioavailability, an attempt will be made to formulate gastric retentive drug delivery system for sustained release which is expected to be a better dosage form when compared to conventional or immediate release dosage. In this study the bioavailability of the Cefuroxime axetil increase by using various concentration of HPMC K4M, Carbopol 934P and Sodium bicarbonate for swelling, mucoadhesive and floating behavior respectively. Bioadhesive strength depends upon carbopol 934P as concentration of polymer increases bioadhesive strength also increases. HPMC K4M is water Swellable but Carbopol 934P is hydrogel in nature it restricts movement of polymer and affects the swelling index.

Keywords: Floating-mucoadhesive, HPMC K4M, Carbopol 934P, Cefuroxime Axetil.

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