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Abstract

DEVELOPMENT AND VALIDATION OF A NOVEL STABILITY INDICATING RPHPLC METHOD FOR SIMULTANEOUS ESTIMATION OF PERINDOPRIL, INDAPAMIDE AND AMLODIPINE IN BULK AND COMBINED TABLET DOSAGE FORMS

Gandla. Kumara Swamy*, JM Rajendra Kumar and J. V. L. N. Seshagiri Rao

ABSTRACT

An accurate and precise linear stability indicating RP-HPLC method is proposed for simultaneous determination of Perindopril, Indapamide and Amlodipine in bulk sample and Combined Tablet dosage forms.The analysis was carried out on a zodiac Sil RP C18 Coloun using Mixture of potassium dihydrogen phosphate buffer (pH 3.0) and Acetonitrile in70:30 %v/v ratio at flow rate of 1.0 mL/min thedetection was carried out 260 nm. The retention times were found to be 1.76, 2.24 and3.176 min. for Perindopril, Indapamide and Amlodipine. Linearity was observed in the concentration ranges of 50-250μg/mL for Perindopril, Amlodipine 10-50 μg/ml for Indapamide. The percent recoveries were found to be 100.88 and 99.50% for Perindopril, Amlodipine. 100.62% for Indapamide.(average % recoveries ).for the limit quantifications for found to be 9.8,9.05 and 8.05 μg/mL for Perindopril, Indapamide and Amlodipine respectively Forced degradation studies on the drugs in combinations were also carried out and results present it.

Keywords: RP-HPLC Perindopril, Indapamide and Amlodipine, Forced Degradation Studies; Tablet Dosage Form.


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