WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

RESTORATIVE EFFECT OF CURCUMA LONGA ON ESTROGEN AND UTERUS OF CHLORPYRIFOS EXPOSED MICE

Anshupriya2, *Ranjit Kumar1, Preety Sinha2, A. Nath1, J.K.Singh1, Md Ali1 and Arun Kumar1

1Mahavir Cancer Institute & Research Centre, Phulwarisharif, Patna (Bihar), India
2 A. N. College, Magadh University, Bodh Gaya, Bihar, India.

ABSTRACT

Pesticides are considered a vital component of modern farming. They are used to control organisms that are considered to be harmful. They are also used in grocery stores and food storage facilities to manage rodents and insects that infest food such as grain. Now a day’s preterm birth, spontaneous abortion and miscarriages are very common problem. In this experiment bioremedial effect of Curcuma longa on uterus and estrogen level of chloropyrifos induced mice were studied in detailed. The control group of mice received distilled water as drinking water. The ‘treatment’ groups received Chlorpyrifos 6 mg/kg b.w daily by Gavage method for two, four and eight weeks followed by four and eight weeks administration of alcoholic extract of root of Curcuma longa (50 mg/kg/b.w/day). Animals were sacrificed after the scheduled treatment. Chloropyrifos causes increase in estrogen level. Degenerated endometrium and muscular layer was observed. Frequent vacuolization was observed in stroma layer. While Curcuma longa causes restoration in estrogen level. Endometrial layer and endometrial gland were restored to greater extent. Muscular layer was almost normal like. Thus it is concluded from entire study that Curcuma longa restores uterus effectively and decreases chances of miscarriage, preterm birth and spontaneous abortions.

Keywords:


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More