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Abstract

EXCIPIENTS USED IN SELF NANOEMULSIFYING DRUG DELIVERY SYSTEMS

*Swathi Bagadi.

ABSTRACT

Out of newly discovered drugs most of the drugs are found to be lipophilic and are poorly water soluble, which leads to poor oral bioavailability. Currently a number of technologies are available to deal with poor solubility, dissolution rate and bioavailability of insoluble drugs. Recently more attention has been focused on lipid based formulations with particular emphasis on self emulsifying drug delivery systems (SEDDS). These are isotropic mixtures of oil, surfactants, and co-solvents or co-surfactants. The principal characteristic of these systems is their ability to form fine oil in water emulsion or microemulsion upon dilution followed by mild agitation with the aqueous fluids which presents drug in solubilized form, and the small size of droplets formed provides large interfacial surface area for drug absorption. For lipophilic drugs which exhibits dissolution rate limited absorption, SEDDS are promising approach to improve the rate and extent of oral absorption.

Keywords: Emulsion, microemulsion, lipophilic and SEDDS.


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