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Abstract

EVALUATING THE ANTI-SHIGELLOSIS ACTIVITY OF FEW EDIBLE MUSHROOMS AGAINST MULTIDRUG RESISTANT SHIGELLA SP.

Debasmita Chatterjee*, Dipankar Halder, Urmita Chakraborty, Devarati Dutta, Prabir Kuila and Satadal Das

ABSTRACT

Mushrooms are of immense significance in the field of research for many years, because of its high nutritional and pharmaceutical importance. Many wild and edible mushrooms have showed varied medicinal importance be it antineoplastic, antiatherosclerotic, antiviral and antimicrobial activities. In the present study we have showed a comparative analysis of antibacterial activities of alcoholic and aqueous extracts of five edible mushrooms of genus Pleurotus and Calocybe specifically P.ostreatus, P.florida, P.eous, P.sajor-caju and C.indica against Shigella spp., as very few research studies are available against Shigellosis, which is a prevalent dysenteric disease in developing countries especially in children. In this study we have also studied antibacterial activity against one multidrug resistant Shigella sp. A detailed comparative analysis of the phytochemical constituents of all the mushroom extracts was done and the antimicrobial activity was correlated with the phytochemical constituents of the mushrooms. Results showed that only the ethanol extracts of all the mushrooms showed potent activity against the multidrug resistant strain showing MIC in the range of 0.94mg/mL- 15mg/mL. The enhanced antibacterial activity of the ethanol extract in comparison to the hot water extract was probably due to the significant difference (Two way ANOVA, P value < 0.0001) of the secondary metabolite -phenol content of the extracts. The results also indicated possible higher phenol content is responsible for maximum antibacterial activity of oyster mushrooms P.ostreatus.

Keywords: Mushrooms, antibacterial activity, Shigellosis, phenol compounds.


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