WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

APPLICATION OF TWO NOVEL SPECTROPHOTOMETRIC METHODS FOR SIMULTANEOUS ESTIMATION OF LOSARTAN POTASSIUM AND CHLORTALIDONE IN PHARMACEUTICAL DOSAGE FORM

Soniya A Thomas* and Mary Mathew

ABSTRACT

Objective: To develop two novel, simple, specific and accurate spectrophotometric methods for simultaneous estimation of Losartan Potassium and Chlortalidone without prior separation steps. Methods: Ratio difference spectrophotometric method (RDSM) and mean centering of ratio spectra method (MCR). Results: Calibration curves of the two methods are linear over the concentration range of 10-40μg/ml and 10-60μg/ml for Losartan Potassium and chlortalidone respectively, with good correlation coefficients. The methods were validated as per ICH guidelines; accuracy, precision and repeatability are found to be within acceptable limit. Conclusion: The two novel spectrophotometric methods are simple, accurate, precise, reproducible, economic and valid for application in laboratories lacking liquid chromatographic instruments.

Keywords: Losartan Potassium, Chlortalidone, ratio difference spectrophotometric method, mean centering of ratio spectra.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More