TRANSUNGUAL DRUG DELIVERY SYSTEMS-RECENT ADVANCES AND MARKETED PRODUCTS
*Sharma Sonam1, Choudhary Santanu Roy1, Hallan Supandeep Singh2
1Department of pharmaceutics Sri Sai college of pharmacy Badhani, Pathankot, India.
2Department of pharmaceutics ISF College of pharmacy, Moga Punjab, India.
ABSTRACT
Transungual drug delivery system is associated with the drug delivery
through the hard keratinized nail plate to treat the diseases of nail itself
in conditions like onychomycosis and nail psoriasis, this review is
focusing mainly on nail lacquers which have been used as cosmetics
since a long time for beautification and protection of nails. These can
also be used as a drug delivery system. Medicated nail lacquers are the
formulations that are used for transungual drug delivery for maximal
antifungal efficacy. The factors, which affect the drug uptake and
permeation of drug through the nail plate, are solute molecular size,
hydrophilicity / hydrophobicity, charge, and the nature of the vehicle,
followed by ways of enhancing drug transport into and through the nail
plate. The film formed after application of nail lacquer on the nail surface acts as a drug depot
that permits optimized and sustained diffusion across the nail and leads to continuous
penetration of active principle to high tissue concentration required for its efficacy. The
present review concluded that the medicated nail lacquers are the efficacious dosage forms
for treating nail disorders. Finally, drug-containing nail lacquers which, like cosmetic
varnish, are brushed onto the nail plates to form a film and from which drug is released and
penetrates into the nail, recent advances and marketed products are reviewed.
Keywords:
[Full Text Article]