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Abstract

PHOTOSTIMULATION OF WOUND HEALING AND HAIR GROWTH OF SWISS ALBINO MICE UTILIZING LOW POWER LASER

Mohemid M Al-Jebouri* and Balsam Y Al-Shakarji

ABSTRACT

Background: Many studies have demonstrated a bactericidal effect of laser irradiation toward apportunistic bacteria. Laser is a device capable of producing a beam of light that consist of parallel waves. This tool as a new photochemotherapeutic is used directly and induced microbial killing of photosensitized organism pending in vivo study. As well as uses applications in various fields of biology and medicine like wound healing. Methodology: Swiss albino mice were taken from Institute of the Biological and Pharmaceutical Research Laboratory (Baghdad). Low power laser,photosensitizer and antibiotic were used for treatment of wounded mice and infected with Pseudomonas aeruginosa. Results: It was concluded that Ps.aeruginosa could be killed by low-power diode laser in combination with photochemical agents which considered the most effective and most suitable than other agents .Wound healing and hair regrowth were significantly enhanced utilizing low power laser,photosensitizer and selected antibiotic.Conclusions: Povidone –iodine at concentration 256 μg/ml was a good photosensitizer to sensitize P.aeruginosa isolates for killing by low – power diode laser light with different exposure time . The statistical analysis of wound healing according to the type of treatment showed significant differences (P<0.0001) using F-test . The effect of laser exposure on various animal groups was statistically significant also (P<0.0001) using F-test . There was a significant difference between exposed animal groups and control group and the p value was less than 0.0001 using T-test.The time needed to regrowth of shaved hair of the experimental animals was shortened to be half of the time needed for hair regrowth without exposure to laser ,photosensitizer and antibiotic.

Keywords: mice,wound healing,hair growth,laser,photosensitizer,cefotaxime.


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