WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

SYNTHETIC AND PHARMACOLOGICAL EVALUATION OF SOME 3- (4-{[(SUBSTITUTEDPHENYL) METHYLENE] AMINO} PHENYL)-6- BROMO-2-METHYL QUINAZOLIN-4-ONE DERIVATIVES

Ravindra Kumar*, R.K. Shukla, Abha Shukla and Neelam Tyagi

ABSTRACT

A series of ten novel compounds (3a) 3-(4-{[(2-chlorophenyl) methylene] amino}phenyl)-6-bromo-2-methylquinazolin-4-one; (3b) 3-(4-{[(4-chlorophenyl) methylene] amino} phenyl)-6-bromo-2- methylquinazolin-4-one; (3c) 3-(4-{[(3,4-dimethoxyphenyl) methylene] amino} phenyl)-6-bromo-2-methylquinazolin-4-one; (3d) 3-(4-{[(phenylmethylene] amino}phenyl)-6-bromo-2- hylquinazolin-4- one; (3e) 3-(4-{[(2-ydroxyphenyl) methylene] amino} phenyl)-6- bromo-2-methylquinazolin-4-one; (3f) 3-(4-{[(4-hydroxy-3- methoxyphenyl) methylene] amino} phenyl)-6-bromo-2 methylquinazolin-4-one; (3g) 3-(4-{[(4-hydroxyphenyl)methylene] amino} phenyl)-6-bromo-2-methylquinazolin-4-one; (3h) 3-[4-{[(4- (dimethylamino) phenyl) methylene] amino) phenyl]-6-bromo-2- methylquinazolin-4-one; (3i) 3-(4-{[(4-methoxyphenyl) methylene] amino} phenyl)-6- bromo-2-methylquinazolin-4-one ; (3j) 3-(4-{[(3-nitrophenyl) methylene] amino} phenyl)-6- bromo-2-methylquinazolin-4-one (3a -3j) have been synthesized by the reaction between 3- (4-aminophenyl)-6-bromo-2-methylquinazolin-4-one and different substituted aldehydes by using ethanol as a solvent. The newly synthesized compounds were characterized by elemental, IR and mass spectra analysis. The synthesized compounds were evaluated for antibacterial and antifungal activities by Agar diffusion method. All the compounds (3a-3j) were screened for their antibacterial activity against E. coli, S. aureus, B. spizinzenii, P. aeruginosa, S. paratyphi, B. pumillus, K. pneumoniae, and yeast C. albicans by disk diffusion method. Compounds showed good antibacterial activity against Staphylococcus aureus and Bacillus spizinzenii. Compounds 3a -3j exhibited good antifungal activity against Candida albicans fungus.

Keywords: 4-Quinazolinone, 4-Benzoxazinone, Synthesized & Characterized, antibacterial, antifungal.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More