WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

LONG TERM ORAL TOXICITY STUDY OF MIRUTHAR SINGI PARPAM IN WISTER ALBINO RATS

Kanimozhi Rajendiran, Maheshkumar Kuppusamy*, Dilara Kamaldeen, Salaikarthikaiyan Thangamani

ABSTRACT

Hemorrhoid (Piles) is one of the leading lifestyle disorders affecting most of the common people. In Siddha system of medicine, MIRUTHAR SINGI PARPAM (MSP), a herbo mineral (lead) preparation is mostly used for treating Hemorrhoids. Herbo-mineral formulations are gaining worldwide importance due to its nano form, increased bioavailability, minimal side effect and less dosage. We already evaluated the preparation, standardization and acute toxicity study (72hr) of MSP and so the present study was conducted to check the safety of this drug in the long term (90days) use. For that four different group of animals in which MSP was administered orally once a day at various doses (0.702 mg/kg, 3.51 mg/kg, and 7.02 mg/kg) and control animals received only saline water for 90 days. Throughout the experimental period no mortality was observed. Food and water intake of the experimental group animals were found in normal range. Hematological, biochemical parameters and histopathological evaluation of the organs was performed in all groups of animals. No impairment in Haemopoietic Lipid profile, Liver function and Kidney function was observed in study group animals. Histopathological study revealed that Heart, Lung, Stomach, Liver, Brain and Kidney organs did not show any signs of toxicity. MSP was found to be non-toxic in testing doses and hence a safe herbo-metal preparation for long term therapeutic use.

Keywords: Siddha, Hemorrhoids, Long term, Toxicity.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More