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Abstract

EFFECT ON THE PITUITARY-TESTICULAR AXIS IN STREPTOZOTOCIN INDUCED DIABETIC RATS

Mr. Kishwor Bhandari*, Dr. Aruna Mukherjee, Dr. Ipseeta Ray, Mrs. Sanju Acharya

ABSTRACT

Diabetes affects sexual dysfunction in male. Testis represents the central organ of male reproductive system. Its function is primarily controlled by gonadotropins which are protein hormones secreted by gonadotrope cells of the pars anterior of the pituitary gland. The two principal gonadotropins are luteinizing hormone (LH) and follicle stimulating hormone (FSH).These hormones are central to the complex endocrine system that regulates normal growth, sexual development and reproductive function. LH acts on Leydig cells to produce testosterone. Follicle stimulating hormone and testosterone hormone both acts on Sertoli cells to regulate spermatogenesis. Diabetes mellitus is an endocrine disorder. To analyze the hormone of the pituitary testicular axis in diabetic conditions, adult male wistar rats were induced into diabetes mellitus by intraperitoneal injection of streptozotocin. The rats were maintain in the diabetic state till one week, one month and six months according to the duration of study. Determination of the serum level of gonadotropins and testosterone hormone in the serum of both diabetic and non diabetic rats was done. Significant decrease (p<0.05) in serum level of FSH, LH and testosterone hormone was found in the diabetic group after one and six months.

Keywords: Diabetes mellitus, Follicle stimulating hormone, Luteinizing hormone, Testosterone.


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