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Abstract

TO EVALUATE THE EFFICIENCY OF THE SECOND-TRIMESTER SCREENING (QUAD TEST) FOR FETAL CHROMOSOMAL ABNORMALITIES IN AHVAZ, IRAN

Najmeieh Saadati, Sara Masihi, Mahin najafian, Maryam Mosavi Alizadeh*

ABSTRACT

Objective: To evaluate the efficiency of quad test screening for chromosomal abnormalities in Ahvaz (Iran). Materials And Methods: Mternal serum concentrations of α-fetoprotein, human chorionic gonadotropin, unconjugated esteriol, and inhibin-A were measured among 907 pregnant women from 15 to20 weeks of gestation during March 2013 to July 2014. Risk calculation, screenpositive rate and detection rate for chromosomal abnormalities were determined. Results: 190 women with high risk and 18 women with intermediate risk in the initial screening test decided to have invasive procedure for genetic diagnosis. Three cases of Down syndrome and one case of trsomy 13 were detected prenatally. Also, one case with Down syndrome was detected in follow-up despite a low estimated risk in screening test. The detection rate for Down syndrome was 75% (three out of four cases), with a 12% false-positive rate. Conclusion: The detection rate of quad test for Down syndrome in Ahvaz is very similar to the previous studies. But, falsepositive rate is higher than found in previous studies. Therefore, a study with a larger sample size is needed to determine standard multiple of medians (MoMs) for serum makers among Iranian women for use in risk assessment software.

Keywords: Down syndrome (trsomy 21), quad test, second-trimester, trisomy18, trisomy 13, Amniocentesis.


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