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Abstract

EVALUATION OF ANTITUMOR EFFECT OF METHYLXANTHINE FRACTION ISOLATED FROM PU-ERH TEA

Kaloyan Georgiev*, Ivan Iliev and Iliya Jelev

ABSTRACT

In this study we investigated the effects of methylxanthine fraction
extracted from the Pu-erh tea leaves against human colon carcinoma
cell line HT-29, human breast carcinoma cell line MDA-MB-231 and
healthy cell lines – BALB/3T3 and BJ. We used different
concentrations of the methylxanthine fraction (2 – 1000 μg/ml) on the
cultured cells and incubated them for 24 and 72 h. The cytotoxic
effects were measured by the MTT dye reduction assay. The
methylxanthine fraction extracted from Pu-erh tea has shown
concentration-dependent cytotoxicity on colon and breast carcinoma
cell lines. The combination of methylxanthine fraction and oxaliplatin
did not result in synergism.

Keywords: Camellia sinensis, Pu-erh tea, green tea, anticancer, methylxanthine, caffeine.


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