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Abstract

EXTRA CELLULAR ABILITY OF BACILLUS SUBTILIS AND PSEUDOMONAS FLUORESCENS TO DEGRADE AFLATOXIN B1 PRODUCED BY ASPERGILLUS FLAVUS

Labeed A. Al-Saad*, Adnan I. Al-Badran, Sami A. Al-Jumayli

ABSTRACT

This study was designed to evaluate the extra cellular ability of Bacillus subtilis isolates (BSS1, BSS2, BSS3, BSS4 and BSW) and Pseudomonas fluorescens isolates (PFMst and PFDL) to degrade aflatoxin B1 (AFB1) that produced by Aspergillus flavus AFL14. The extra-cellular degradation ability of bacterial isolates to AFB1 was evaluated quantitatively using HPTLC technique. B. subtilis isolates BSS4, BSW and BSS3 were exceeded the rest of bacterial isolates significantly (100, 100 and 99.55) % respectively, followed by P. fluorescens isolates PFMst and PFDL (97.805 and 97.396) % respectively, with no significant differences among individuals in the same group. The degradation residues administrated to rats to determine their effect on biosystems, the blood parameters showed a significant reduction in WBC, HB, RBC, and P.C.V while there was a significant increase in Urea, Glutamic pyrovate transaminase (GPT) and Glutamic oxaloacetic transaminase (GOT) in AF+DMSO treatment comparing with the negative and positive control which is may indicate that AFB1 caused immune-malfunction, hemolysis, kidney malfunction and liver stress. The biocontrol treatments showed a significant increase in WBC caused by BSS4+AF treatment, significant reduction in RBC caused by BSS4 and PFMst and significantly high Urea levels exceeded AF+DMSO treatment caused by PFMst and PFMst+AF treatments respectively. According to platelet count parameter, no significant differences were observes among all treatments and control treatments.

Keywords: Aspergillus flavus, aflatoxin B1, extra-cellular, degradation, Pseudomonas fluorescens, Bacillus subtilis.


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