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Abstract

THE EFFECTS OF AQUEOUS LEAF EXTRACT OF SYMPHYTUM OFFICINALE (COMMON COMFREY) ON THE LIVER ENZYMES OF ADULT WISTAR RATS.

*Ezejindu DN, Udemezue OO, Anyabolu AE, Chukwujekwu IE, Akingboye AJ, Obialor DC, Anike LC, Ihim AC

ABSTRACT

Symphytum officinale (common comfrey) has been used as herbal to treat wounds and to decrease pain and inflammation. Its effect on the liver enzymes aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) were the main focus of this study. Twenty wistar rats of an average weight of 219g were used for the study and were divided into four (4) groups (A, B, C and D) of five animals each. Group A served as the control and received 0.3ml of distilled water; the experimental groups B, C and D were orally administered 0.4ml, 0.6ml and 0.8ml of aqueous extract of symphytum officinale leaf for twenty eight (28) days respectively. Twenty four (24) hours, after the last administration, the animals were anaesthetized under chloroform vapour and dissected. About 5ml of blood was collected from animals in all the groups by cardiac puncture using sterile syringe and needles, liver organs were also harvested and weighed, blood for serum preparation was collected into sterile plain tubes and stored in the refrigerator for analysis. The activities of serum aspartate aminotransferase (AST), Alanine aminotransferase (ALT) and alkaline phosphatase (ALP) were determined using radox kit method. The results showed that there was a significant increase (P<0.005) in the activity levels of aspartate aminotransferase (AST), alanine aminotransferase, (ALT), and alkaline phosphatase (ALP) in groups C and D relative to group A (Control). Alkaline phosphatase (ALP) activity level of group B also increases significantly. Group B also recorded a little increase in activity levels of AST and ALT but it is not statistically significant. Thus, chronic consumption of aqueous extract of symphytum officinale (common comfrey) may cause biochemical alterations in the liver enzymes.

Keywords: Symphytum officinale, Wistar rats, Blood samples, liver organ, Biochemical alterations.


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