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Abstract

DETECTION OF BCR-ABL FUSION SIGNAL IN PERIPHERAL BLOOD CELLS OF APPARENTLY HEALTHY INDIVIDUALS BY USING FISH TECHNIQUE

Dr. Farha A. Ali Shafi*, Dr. Ban A. Abdul Majeed and Dr. Nada AL-Ansari

ABSTRACT

The Philadelphia (Ph) chromosome which results from translocation t(9;22), it is acquired cytogenetic abnormality that characterizes all leukaemic cells in CML. The (9;22) translocation generates the break cluster region –c-abl oncogene 1 (BCR-ABL ) fusion gene on the Ph chromosome and also a reciprocal fusion gene, designated ABL1 – BCR on the derivative 9q+ chromosome. Measurement of gene fusions in peripheral blood cells of normal individuals may be used as a sensitive assay for the detection of genomic instability, and may contribute to risk estimation for development of lymphoid malignancies. The present study aimed to investigate the presence of bcr‑abl fusion gene in the peripheral blood of healthy individuals by using Fluorescence in situ hybridization (FISH) technique. Detection of BCR-ABL fusion signal in apparently healthy Iraqi population is reported for the first time in the present study. BCR-ABL fusion signal was detected in(10/18 ,55%) of study sample and in(18/20,90%) of CML patients There was a significant difference between CML cases and sample study regarding signal positive score(P<0.0001). All sample had low score. (33.3%) of CML cases had high score,(27.8%) had intermediate score, (38.8%) had low score . detecting BCR-ABL fusion signal in peripheral cells of healthy individuals reflect long term exposure to carcinogens consequently they may aid in leading to tumor formation.

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