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Abstract

IN VITRO EVALUATION OF THE ACTIVITY OF AQUEOUS EXTRACT OF A PLANT CODED PHYLLAM (PHYLLANTHUS AMARUS) ON TWO STRAINS OF MYCOBACTERUM TUBERCULOSIS AND ONE STRAIN OF MYCOBACTERUM ULCERANS

Trebissou Jonhson Noel D1*, Beourou S2, Lohoues Essis Esmel C4, Yapi Houphouet F1, Boga Gogo L1, Djaman Allico J1,3.

1Pharmacodynamics Biochemical Laboratory, UFR Biosciences, Felix Houphouet Boigny University. PO Box, 582, Abidjan 22- Côte d’Ivoire.
2Malariology Unit and Laboratory of CNR Chemoresitance, Pasteur Institute of Côte d’Ivoire, PO. BOX, 01 BP 490 Abidjan, 01
3Laboratory of Basic and Clinical Biochemistry, Pasteur Institute of Cote d’Ivoire.PO. Box, 01 BP 490 Abidjan 01
4Biochemical Laboratory, UFR medical Sciences, Felix Houphouet Boigny University. PO Box, 582, Abidjan 22- Côte d’Ivoire.

ABSTRACT

Burili ulcer and tuberculosis are diseases caused by mycobacteria and are a real public health problem in Côte d'Ivoire. We evaluated the activity of the aqueous extract of Phyllanthus amarus on the in vitro growth of two strains of M.tuberculosis (H37Rv and RF94) and one strain of M. ulcerans recorded under the name (02003). The results showed that all strains tested were susceptible to the aqueous extract of Phyllanthus amarus with minimum inhibitory concentrations (MIC) of 16 mg / ml for RF94 and 64 mg / ml for H37Rv and 02003 strains. This study shows that it is necessary to widen our research on more extracts tested in vitro and in vivo to enhance the bactericidal activity of Phyllanthus amarus.

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