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Abstract

A REVIEW ON EXTENDED RELEASE DRUG DELIVERY SYSTEM AND MULTIPARTICULATE SYSTEM

Mr. Samir J. Shah*, Dr. Paresh B. Shah Dr. Mukesh S. Patel, Dr. Mukesh R. Patel

ABSTRACT

Recently, extended release pharmaceutical products became a very useful tool in medical practice, offering a wide range of actual and perceived advantages to the patients. Oral drug delivery is the most preferred route for the various drug molecules among all other routes of drug delivery, because ease of administration which lead to better patient compliance. So, oral extended release drug delivery system becomes a very promising approach for those drugs that are given orally but having the shorter half-life and high dosing frequency. Extended release is also providing promising way to decrease the side effect of drug by preventing the fluctuation of the therapeutic concentration of the drug in the body. Oral extended release drug delivery medication will continue to account for the largest share of drug delivery systems. The extended release product will optimize therapeutic effect and safety of a drug at the same time improving the patient convenience and compliance. Recent trends indicate that multiparticulate drug delivery systems are especially suitable for achieving extended release oral formulations with low risk of dose dumping, flexibility of blending to attain different release patterns as well as reproducible and short gastric residence time. The release of drug from pellets depends on a variety of factors including the carrier used to form pellets and the amount of drug contained in them. Consequently, pellets provide tremendous opportunities for designing new controlled and extended release oral formulations, thus extending the frontier of future pharmaceutical development.

Keywords: Extended Release, Oral route, Therapeutic concentration, Pellet, Dosage form.


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