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Abstract

A REVIEW ON ANALYTICAL METHODS FOR DETERMINATION OF DICYCLOMINE HYDROCHLORIDE IN PHARMACEUTICAL DOSAGE FORMS AND BIOLOGICAL SAMPLES

Malathi Raghunath*, Amol Arun Dhamne and Jyotsna Gajanan Patil

ABSTRACT

Dicyclomine Hydrochloride (DIC) is an antimuscarinic and antispasmodic agent. DIC is used to treat a certain type of intestinal problem called irritable bowel syndrome. It helps to reduce the symptoms of stomach and intestinal cramping. Its action is achieved via dual mechanisms; due to a specific anticholinergic effect at the acetylcholine-receptor sites and a direct effect upon smooth muscle. The drug is official in Indian Pharmacopoeia, United States Pharmacopoeia and British Pharmacopoeia. Many analytical methods have been reported for simultaneous estimation of DIC in its combined pharmaceutical dosage form but only fewer methods have been reported for estimation of DIC alone in pharmaceutical dosage forms. DIC is an important active pharmaceutical ingredient used even in children to relieve colic pain. This review therefore focuses on analytical methods reported for the estimation of DIC in literature and any further scope of developing novel instrumental analytical methods for estimation of DIC alone and in its fixed dose combinations.

Keywords: DIC hydrochloride, Spectrophotometry, Chromatography, Potentiometry, Calorimetry, Antispasmodic.


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