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Juneboina Nagahussain Rao*, Chandana kamili, Sushma M, Uma Maheswararao V


Angiogenesis is the extension of blood vessels from the pre existed vasculature. It is an important process which involves the formation and development of blood vessels, so it is supportive in healing of wound while its inhibition may help to restrict the size of tumor. The angiogenesis activity was involved in many physiological and pathological conditions. When this balance is disturbed, the result is either too much or too little angiogenesis. The body controls angiogenesis by producing a precise balance of growth and inhibitory factors in healthy tissues. Excessive angiogenesis occurs in diseases such as cancer, diabetic blindness, age-related macular degeneration, rheumatoid arthritis, psoriasis and for these Anti angiogenic therapies are aimed to halt new blood vessel growth. Insufficient angiogenesis occurs in diseases such as coronary artery disease, stroke, and chronic wounds. Therapeutic angiogenesis aimed to stimulate new blood vessel growth with growth factors is being developed to treat these conditions. Angiogenic gene therapy is also being developed as a method to deliver angiogenic growth factors to the heart, limbs, and wounds. Currently there is no angiogenic gene therapy and drugs approved by FDA for the treatment of ischemic cardiovascular disease. But FDA approved device is used to stimulate NBV to grow in diseased hearts is a laser used in a technique called Direct Myocardial Revascularization.

Keywords: Angiogenesis, physiological and pathological conditions.

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